Figure 1.

Vacuolation profiles for atypical scrapie, classical scrapie and BSE in AHQ/AHQ sheep. See Table 1 for details of the cases, and Table 3 for area code key, and mean ± SD for each data point. a) The profiles for the classical scrapie (pink, cases 15-17) and ovine BSE (blue, cases 10-14) cases are similar, particularly in terms of brainstem involvement, whereas the atypical scrapie profile (green, cases 1-9) has distinctive peaks in the cerebellum (area 12) and frontal cortex (area 20). b) The vacuolation profiles for experimental atypical scrapie cases subdivided by passage. The profile from the original challenged animals (green, cases 1-4 and 8-9) is very similar to that in the animals that succumbed to disease following sub-passage (red, cases 5-7).