Table 1.
Individual case data of genotype, breed, inoculum, route of inoculation, incubation periods and clinical signs
| Case no | Breed/genotype | Challenged with | Route | Age at challenge (months) | Ip (days) | Clinical signs |
|---|---|---|---|---|---|---|
| 1* | Cheviot AHQ/AHQ | AHQ -atypical passive (PG1347/04) Portland | Intracerebral | 5.5 | 378 | Behavioural changes (confusion, separation from others), compulsive behaviour (spontaneous nibbling, circling clockwise), mild hind limb ataxia, weight loss, normal menace response, no signs of pruritus |
| 2 | Cheviot AHQ/AHQ | As above | Intracerebral | 5.5 | 1057 | Compulsive behaviour (circling anti-clockwise), absent menace response in the left eye, head tremor, general ataxia, no weight loss, no signs of pruritus |
| 3 | Cheviot AHQ/AHQ | Active surveillance - breed not known | Intracerebral | 5.5 | 878 | Behavioural change (nervousness), bilateral absent menace response, head tremor, general ataxia, minor weight loss |
| 4 | Cheviot AHQ/AHQ | Same case as above | Intracerebral | 6 | 990 | Behavioural changes (confusion, separation from others), bilateral absent menace response, head tremor, general ataxia, no weight loss, no signs of pruritus |
| 5 | Cheviot AHQ/AHQ | Subpassage of material from case 1 | Intracerebral | 3 | 667 | No behavioural changes, bilateral absent menace response, general ataxia, no weight loss, no signs of pruritus |
| 6 | Cheviot AHQ/AHQ | Subpassage of material from case 1 | Intracerebral | 3 | 747 | Compulsive behaviour (circling anti-clockwise), bilateral absent menace response, head tremor, general ataxia & hypermetria, minor weight loss, no signs of pruritus |
| 7 | Cheviot AHQ/AHQ | Subpassage of material from case 1 | Intracerebral | 3 | 671 | Behavioural changes (confusion), bilateral absent menace response, head tremor, general ataxia, minor weight loss, no signs of pruritus |
| 8 | Cheviot AHQ/AHQ | (PG519/06) AHQ/AHQ passive case - Cheviot | Intracerebral | 3 | 607 | Behaviour changes (dullness, teeth grinding), normal menace response, head tremor, general ataxia, weight loss, no signs of pruritus |
| 9 | Cheviot AHQ/AHQ | (PG519/06) AHQ/AHQ passive case - Cheviot | Intracerebral | 3 | 833 | Behavioural changes (confusion, separation from others), compulsive behaviour (circling anti-clockwise), normal menace response, general ataxia, minor weight loss, no signs of pruritus |
| 10 | Cheviot AHQ/AHQ | Bovine BSE | oral | 4 | 573 | Abnormal behaviour (confusion), signs of pruritus (frequent rubbing, positive scratch test, wool loss), mild ataxia |
| 11 | Cheviot AHQ/AHQ | Bovine BSE | oral | 4.5 | 595 | Head tremor, signs of pruritus (frequent rubbing, wool loss, positive scratch test), minor weight loss |
| 12 | Cheviot AHQ/AHQ | Bovine BSE | oral | 4.5 | 617 | Signs of pruritus (wool loss), weight loss |
| 13 | Cheviot AHQ/AHQ | Bovine BSE | oral | 8 | 642 | Abnormal behaviour (separation from others), normal menace response, head tremor, signs or pruritus (frequent rubbing), mild ataxia, weight loss |
| 14 | Cheviot AHQ/AHQ | Bovine BSE | oral | 4.5 | 664 | Abnormal behaviour (teeth grinding), signs of pruritus (frequent rubbing, wool loss), weight loss |
| 15 | British milksheep X Finn Dorset AHQ/AHQ | Classical scrapie | Natural | Not applicable | 9 years at clinical onset | Abnormal behaviour (teeth grinding), ataxia, no signs of pruritus |
| 16 | British milksheep X Finn Dorset AHQ/AHQ | Classical scrapie | Natural | Not applicable | 5 years at clinical onset | No behavioural abnormalities, mild ataxia, pruritus (positive scratch test) |
| 17 | British milksheep X Finn Dorset AHQ/AHQ | Classical scrapie | Natural | Not applicable | 3 years 9 months at clinical onset | No behavioural abnormalities, mild ataxia, signs of pruritus (frequent rubbing) |
| 18 | Cheviot ARQ/VRQ | Classical scrapie | Intracerebral | 10 | 537 | Abnormal behaviour (nervousness, separation from others), normal menace response, head & body tremor, signs of pruritus (positive scratch test, rubbing with nibble reflex), ataxia, weight loss |
| 19 | Dorset ARQ/VRQ | Classical scrapie | Intracerebral | 10 | 605 | Abnormal behaviour (nervousness), normal menace response, head tremor, signs of pruritus (rubbing with nibble reflex), mild ataxia, weight loss |
| 20 | Dorset VRQ/VRQ | Classical scrapie | Intracerebral | 11 | 126 | Abnormal behaviour (dullness), absent menace response in the eye, signs of pruritus (positive scratch test, frequent rubbing), hind limb ataxia, minor weight loss |
Ip = incubation period.
* This case previously reported [13].