Table 3.
Vacuolation scores for each neuroanatomical area in each group of AHQ/AHQ cases
| Mean vacuolation score (± SD) | |||||
|---|---|---|---|---|---|
| Area Code | Neuroanatomical area | Atypical Primary challenge | Atypical Sub-passage | Classical scrapie | Ovine BSE |
| (n = 4) | (n = 2) | (n = 3) | (n = 5) | ||
| 1 | Dorsal nucleus of the vagus | 0.00 (± 0.00) | 0.00 (± 0.00) | 2.33 (± 0.58) | 3.20 (± 0.84) |
| 2 | Hypoglossal nucleus | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.60 (± 0.55) |
| 3 | Reticular formation | 0.00 (± 0.00) | 0.00 (± 0.00) | 2.66 (± 0.58) | 3.00 (± 0.71) |
| 4 | Midline raphe (caudal) | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.66 (± 0.58) | 1.00 (± 0.82) |
| 5 | Accessory cuneate nucleus | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.00 (± 0.00) | 1.00 (± 0.71) |
| 6 | Olivary nuclei | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.33 (± 0.58) | 0.00 (± 0.00) |
| 7 | Vestibular complex | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.00 (± 0.00) |
| 8 | Cochlear nucleus | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.00 (± 0.00) |
| 9 | Nucleus of the spinal tract of the trigeminal nerve | 0.00 (± 0.00) | 0.00 (± 0.00) | 1.00 (± 1.00) | 1.80 (± 0.84) |
| 10 | Midline raphe (rostral) | 0.00 (± 0.00) | 0.00 (± 0.00) | 2.33 (± 0.58) | 0.67 (± 0.58) |
| 11 | Cerebellar vermis - nodulus | 1.00 (± 0.82) | 2.00 (± 1.41) | 0.00 (± 0.00) | 0.25 (± 0.50) |
| 12 | Cerebellar vermis -excluding nodulus | 1.75 (± 1.26) | 3.00 (± 0.00) | 0.00 (± 0.00) | 0.00 (± 0.00) |
| 13 | Central grey matter | 0.00 (± 0.00) | 0.00 (± 0.00) | 2.33 (± 0.58) | 1.60 (± 0.55) |
| 14 | Red nucleus | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.33 (± 0.58) | 0.00 (± 0.00) |
| 15 | Substantia nigra | 0.50 (± 0.58) | 0.00 (± 0.00) | 3.66 (± 0.58) | 1.80 (± 1.30) |
| 16 | Lateral geniculate nucleus | 0.00 (± 0.00) | 0.00 (± 0.00) | 0.66 (± 0.58) | 0.20 (± 0.45) |
| 17 | Dorsomedial thalamic nuclei | 0.05 (± 0.58) | 0.50 (± 0.71) | 3.00 (± 0.00) | 1.40 (± 1.14) |
| 18 | Ventrolateral thalamic nuclei | 1.00 (± 0.00) | 0.00 (± 0.00) | 1.66 (± 0.58) | 0.00 (± 0.00) |
| 19 | Hypothalamus | 0.00 (± 0.00) | 0.00 (± 0.00) | 3.33 (± 0.58) | 1.80 (± 0.84) |
| 20 | Head of the caudate nucleus | 2.50 (± 1.00) | 3.00 (± 0.00) | 0.66 (± 1.15) | 1.20 (± 0.84) |
| 21 | Nucleus accumbens | 1.00 (± 0.82) | 2.00 (± 1.41) | 2.00 (± 2.00) | 0.40 (± 0.55) |
| 22 | Frontal cortex | 2.25 (± 0.96) | 3.00 (± 1.41) | 0.00 (± 0.00) | 0.00 (± 0.00) |
See also Figure 1.