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ALDH inhibition in K562 cells for lead compounds.
| Compound (15 μM) | ALDH+ K562 cells (%) | ALDH Inhibition (%) |
|---|---|---|
| BAAA (Positive Control) | 40.39 ± 2.21 | 0 |
| DEAB (Negative Control) | 0.53 ± 0.11 | 98.68 |
| 1 (disulfiram) | 17.26 ± 2.21 | 57.26 |
| 3a | 8.3 ± 1.7 | 79.45 |
| 3c | 39.01 ± 0.8 | 3.4 |
| 5d | 36.47 ± 3.82 | 9.8 |
| 5f | 36.9 ± 3.15 | 8.6 |
