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. 2008 Nov 5;80(2):302–310. doi: 10.1095/biolreprod.108.071415

FIG. 2.

FIG. 2.

The effect of IL11 on invasion as assessed by Matrigel invasion assays of (A) HTR-8/SVneo and (B) primary EVTs during 48 h. Interleukin 11 (100 ng/ml) significantly inhibited invasion of HTR-8/SVneo cells during 48 h compared with vehicle-treated controls (***P < 0.001). Positive control, TGFB1 (10 ng/ml) versus control (***P < 0.001). Incubation of HTR-8/SVneo cells with STAT3i but not MAPKi prevented IL11-mediated inhibition of EVT invasion (P > 0.05 versus controls, **P < 0.001 versus IL11 [100 ng/ml]). Data are combined from four independent experiments (quadruplicate wells per treatment) and are expressed as fold-change in cell invasion (±SEM) compared with controls.