FIG. 2.

The administration of dibutyryl-cAMP (db-cAMP) increases macrophage infiltration at the site of analog application. A representative image of CD68 staining, to identify macrophages, shows increased numbers at the infusion site within the cortex of animals receiving db-cAMP (A) as compared to saline controls (B). Measurement of fluorescent intensity within the site of cannula implantation (C; area 1 in A and B) and around (D; perilesional region; area 2) demonstrates that there is a significant increase in CD68 immunoreactive intensity following db-cAMP application. Data is expressed as the mean ± SEM; asterisks indicate p < 0.05.