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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Cancer Res. 2010 Mar 23;70(7):2655–2664. doi: 10.1158/0008-5472.CAN-09-4373

Figure 1. BJ3Z cells are tumorigenic, stimulate angiogenesis and promote estrogen-independent tumor growth.

Figure 1

A. mammary glands of ovx nude mice were injected with RedTomato tagged BJ3Z cells (top panels), ZsGreen tagged MCF-7 cells (central panels) or co-injected with both BJ3Z and MCF-7 cells (bottom panels). Mice were implanted with cellulose control (C; left) or 17β-Estradiol (E2) releasing silastic pellets. Tumors were photographed and representative pictures are shown. B. Tumor growth was monitored for 10 weeks for C (n=5) and E2 (n=10) for each tumor type. Statistically significant differences (* p<0.05) were calculated by two-way ANOVA. C. Neovascularization of tumors was quantified by IHC of fluorescent CD34 positive cells in tumors, in the absence or presence of E2; * p<0.05.