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Non-compartmental analysis results for VCR in tissues
| Non-obese | Obese | |||
|---|---|---|---|---|
| t½,β (min) | t½,γ (hrs) | t½,β (min) | t½,γ (hrs) | |
| Spleen | 25.4 | 43.9 | 11.9 | 49.5 |
| Liver | 36.7 | 22.1 | 23.7 | 30.5 |
| Bone Marrow | 36.2 | 22.6 a | 50.7 | 27.5 |
| Brown Adipose | 6.7 | 18.3 | 12.4 | 12.7 |
| White Adipose | 16.2 | 39.2 | 6.0 | 56.8 |
the terminal half-life of VCR in the bone marrow of non-obese mice represents an accumulation—all other half-lives are decay
