Table 6.
DEGs in immune signaling pathways in Npc1−/− mice
| AGI* |
ILMΔ |
|||||
|---|---|---|---|---|---|---|
| Gene symbol | Gene name | Description | FC | P | FC | P |
| B cell receptor signaling pathway | ||||||
| NM_008528 | Blnk*Δ | B-cell linker | 2.4 | 0.000 | 1.6 | 0.027 |
| NM_013482 | Btk*Δ | Bruton agammaglobulinemia tyrosine kinase | 2.0 | 0.008 | 1.3 | 0.037 |
| NM_010187 | Fcgr2b*Δ | Fc receptor, IgG, low affinity IIb | 2.5 | 0.000 | 1.6 | 0.000 |
| NM_026820 | Ifitm1*Δ | interferon induced transmembrane protein 1 | 1.5 | 0.001 | 1.8 | 0.001 |
|
NM_011691 |
Vav1*Δ |
vav1 oncogene |
2.2 |
0.005 |
1.4 |
0.005 |
| complement and coagulation cascades pathway | ||||||
| NM_007572 | C1qa*Δ | complement component 1, q subcomponent, alpha polypeptide | 2.3 | 0.000 | 1.9 | 0.000 |
| NM_009777 | C1qb*Δ | complement component 1, q subcomponent, beta polypeptide | 2.2 | 0.001 | 2.3 | 0.001 |
| NM_013484 | C2*Δ | complement component 2 (within H-2S) | 2.3 | 0.000 | 1.9 | 0.001 |
| NM_009778 | C3*Δ | complement component 3 | 2.9 | 0.001 | 1.3 | 0.036 |
|
NM_009776 |
Serping1*Δ |
serine (or cysteine) peptidase inhibitor, clade G, member 1 |
1.3 |
0.010 |
1.4 |
0.015 |
| Leukocyte transendothelial migration pathway | ||||||
| NM_008770 | Cldn11*Δ | claudin 11 | −1.5 | 0.020 | −1.3 | 0.004 |
| NM_019500 | Cldn14*Δ | claudin 14 | −1.4 | 0.046 | −1.4 | 0.013 |
| NM_007806 | Cyba*Δ | cytochrome b-245, alpha polypeptide | 1.7 | 0.006 | 1.7 | 0.001 |
| BC008626 | Icam1*Δ | intercellular adhesion molecule | 2.5 | 0.001 | 1.8 | 0.003 |
| NM_011691 | Vav1*Δ | vavl oncogene | 2.2 | 0.005 | 1.4 | 0.005 |