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Summary graphs of antagonist effects in the locomotor assay. Nalmefene was approximately equipotent to naloxone in blocking the locomotor stimulating effects of a fixed dose of morphine (panel A, 95% confidence intervals overlap). When given at supramaximal doses (1 mg/kg, i.p.), neither antagonist produced a significant effect on locomotor activity compared to vehicle treated mice (panel B, p > 0.05).
