Figure 3.
The reduction of adjuvant arthritis-associated paw swelling by orally administered naproxen and ATB-346 (both at 4 µmol·kg−1 twice-daily). Freund's complete adjuvant was administered on day 0, after the initial paw volume measurement. Results are shown as the summed volumes of the two hindpaws. Treatment with the test drugs or vehicle was carried out from days 7 to 21 after adjuvant administration. Naproxen significantly reduced paw oedema at day 21 (*P < 0.05 vs. the vehicle-treated group), but not at day 14. ATB-346 significantly reduced paw oedema at days 14 and 21 (*P < 0.05 vs. the vehicle-treated group). Each group consisted of six to seven rats (data were compared using anova and Dunnett's Multiple Comparison test). ATB-346, 2-(6-methoxy-napthalen-2-yl)-propionic acid 4-thiocarbamoyl-phenyl ester.