Figure 4.

Oral administration of naproxen caused haemorrhagic damage in the stomach that increased in severity in a dose-dependent manner. In contrast, ATB-346 administration caused markedly less gastric damage at all doses tested; the stomach appeared normal with doses of 30 to 120 µmol·kg⁻¹). At the dose of 2740 µmol·kg⁻¹, there was significantly more damage with naproxen than with ATB-346 (P < 0.001; Student's t-test). Each group consisted of at least five rats. ATB-346, 2-(6-methoxy-napthalen-2-yl)-propionic acid 4-thiocarbamoyl-phenyl ester.