Skip to main content
. 2010 Feb 1;159(6):1264–1273. doi: 10.1111/j.1476-5381.2009.00610.x

Figure 5.

Figure 5

Modulation of the generation of sAPPα and Aβswe induced by the enhanced α-secretase activity observed after nebivolol and E2 treatment. (A) Quantification of sAPPα (elisa). (B) Quantification of Aβ swe (elisa). (C) α-Secretase activity assay; activity was plotted as fold induction normalized to untreated cells (n.t.). Treatments: n.t., untreated; ICI, ICI 182780 at final concentration (f.c) of 10−6 M; E-7, oestrogen f.c. 10−7 M; E-8, oestrogen f.c. 10−8 M, N-6, nebivolol f.c. 10−6 M, N-7, nebivolol f.c. 10−7 M, N-8, nebivolol f.c. 10−8 M. The histograms represent results from more than three independent studies. **P < 0.005, compared with untreated cells of the same kind (anova).