Figure 4.

SAR150640 prevents LPS-induced MMP9 activity and expression. Gelatin zymography analysis (A) with semi-quantification of pro-MMP9 activity (B) and Western blot analysis (C) with semi-quantification (D) showing the expression of MMP9 protein. Legends: CTRL, control time-matched experiments; LPS, 10 µg·mL⁻¹ LPS 48 h; SAR150640 (0.1, 1, 10 µM) was added 20 min prior to LPS stimulation. Experiments were performed, respectively, on four and seven myometrial samples for zymography and Western blot analysis, each obtained from a different woman. ###P < 0.001 versus controls, ***P < 0.001 versus LPS.