FIG. 4.

Recording of bicuculline-induced bursting activity from a hippocampal slice culture (24 DIV) during stretch of the SMEA. 50 μM BIC was applied to the culture to induce robust electrical activity. The SMEA was stretched and released incrementally while activity was continuously recorded at each step. The signal recorded from one electrode is presented: (A) before stretch, (B) 4.8% biaxial strain, (C) 8.1% biaxial strain, (D) 4.0% biaxial strain, (E) 1.6% biaxial strain, and (F) completely released. The noise level increased along with stretch and then recovered after the SMEA was completely released. The initial signal to noise ratio (SNR = 24.6 dB) decreased as the SMEA was stretched, but recovered when it was completely released (SNR = 26.0 dB).