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Macrophage extravasation is seen at 3 days post-injury. CD68 positive cells (green) were detected in the cortex, CA3, and dentate gyrus (DG) regions of hippocampus at 3 days after TBI. However, at 4 h, no CD68-positive cells were present in these regions, indicating that macrophage extravasation is a delayed event after trauma. Red arrows point to macrophages.
