FIG. 4.

RNAs from distal spinal cord segments at 12 h post-injury were subjected to Affymetrix Rat 230.2 genechips. After data normalization, signals from RG3.6-treated samples were compared to medium controls for differential expression. A total of 845 genes reached statistical significance after unpaired t-test with multiple corrections and 60 of them showed ≥ 1.5-fold changes (listed in Table 3). After Ingenuity pathway analysis, four biological networks (I, II, III, IV) were identified with two highlighted, i.e., genes involved in cell proliferation (I) and tissue development (II).