Apoptosis after 90 min ischemia and 3 hours reperfusion in cardiomyocytes from wild-type (WT) and TRPC3 transgenic mice and in TRPC3 cardiomyocytes treated with the L-type calcium channel inhibitor verapamil (VER, 10 μM), the CCE inhibitor SKF96365 (SKF, 0.5 μM) and the calpain inhibitor PD150606 (PD, 25 μM). The untreated WT and TRPC3 data are from the same experiments as those shown in Fig 3B; however the experiments with VER, SKF and PD were performed simultaneously with, and on cells from the same isolations as those in Fig 3. Data presented as mean ± SEM of six individual experiments, i.e., six separate mouse cardiomyocytes isolations; with at least 300 cells counted per experiment under each condition. # = p < 0.05 vs. TRPC3.