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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Cancer Res. 2010 Mar 16;70(7):2984–2993. doi: 10.1158/0008-5472.CAN-09-4040

Figure 1.

Figure 1

Screening of a siRNA library of genes involved in DNA repair in SQ20B and MRC5 cells. A) Irradiated SQ20B cells. Z-scores of the top 30 genes associated with elevated γH2AX foci twenty-four hours after 4Gy radiation. B) Irradiated MRC5 cells. Z-scores of the top 30 genes associated with elevated γH2AX foci twenty-four hours after 4Gy radiation. C) Radiosensitisation of MRC5 cells with APEX2 depletion. Clonogenic assay in MRC5 cells treated with 50nM NT or APEX2 siRNA. **, P < 0.01 unpaired two sided t-test (left). Demonstration of effective knockdown of APEX2 by qRT-PCR. Gene expression normalised to cells treated with NT siRNA (right). D) Unirradiated SQ20B cells. Z-scores of the top 30 genes associated with elevated γH2AX foci in cells transfected with siRNA pools.

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