Table 1.
Summary of somatic mutations in four tumor types. Pancreas data have their basis in 24 tumors analyzed in the current study; brain data have their basis in 21 nonhypermutable tumors analyzed in (15); and colorectal and breast data have their basis in 11 breast and 11 colorectal tumors analyzed in (14). Nonsilent numbers in parentheses refer to percentage of total non-synonymous mutations, and substitutions numbers in parentheses refer to percentage of total substitutions. The total number of substitutions includes synonymous as well as nonsilent mutations identified in the indicated study.
| Pancreas | Brain | Colorectal | Breast | |
|---|---|---|---|---|
| Number of mutated genes | 1007 | 685 | 769 | 1026 |
| Number of nonsilent mutations | 1163 | 748 | 849 | 1112 |
| Missense | 974 (83.7) | 622 (83.2) | 722 (85) | 909 (81.7) |
| Nonsense | 60 (5.2) | 43 (5.7) | 48 (5.7) | 64 (5.8) |
| Insertion | 4 (0.3) | 3 (0.4) | 4 (0.5) | 5 (0.4) |
| Deletion | 43 (3.7) | 46 (6.1) | 27 (3.2) | 78 (7.0) |
| Duplication | 31 (2.7) | 7 (0.9) | 18 (2.1) | 3 (0.3) |
| Splice site or UTR | 51 (4.4) | 27 (3.6) | 30 (3.5) | 53 (4.8) |
| Total number of substitutions | 1484 | 937 | 893 | 1157 |
| Substitutions at C:G base pairs | ||||
| C:G to T:A | 798 (53.8) | 601 (64.1) | 534 (59.8) | 422 (36.5) |
| C:G to G:C | 142 (9.6) | 67 (7.2) | 61 (6.8) | 325 (28.1) |
| C:G to A:T | 246 (16.6) | 114 (12.1) | 130 (14.6) | 175 (15.1) |
| Substitutions at T:A base pairs | ||||
| T:A to C:G | 142 (9.6) | 87 (9.3) | 69 (7.7) | 102 (8.8) |
| T:A to G:C | 79 (5.3) | 24 (2.6) | 59 (6.6) | 57 (4.9) |
| T:A to A:T | 77 (5.2) | 44 (4.7) | 40 (4.5) | 76 (6.6) |
| Substitutions at specific dinucleotides | ||||
| 5′-CpG-3′ | 563 (37.9) | 404 (43.1) | 427 (47.8) | 195 (16.9) |
| 5′-TpC-3′ | 218 (14.7) | 102 (10.9) | 99 (11.1) | 395 (34.1) |