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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2010;49(1):103–107. doi: 10.1002/anie.200905126

Figure 1.

Figure 1

(A): Quantum dots as a multi-functional nanoplatform to deliver siRNA and to elucidate of EGFRvIII- knockdown effect of PI3K signaling pathway in U87-EGFRvIII (B): Detailed structural information of multifunctional siRNA-QDs (C): Two different strategies for the siRNA-QD conjugate. (C1) Linker for attaching siRNA to QDs through a disulfide linkage which was easily reduced within the cells to release the siRNA. (C2) Linker for covalently conjugating siRNA to QDs which enabled tracking of siRNA-QDs within the cells.