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. 2010 Mar 17;98(6):968–978. doi: 10.1016/j.bpj.2009.11.024

Figure 4.

Figure 4

KCl depolarization enhanced exocytosis rates in PC12 cells. (A) Representative traces of exocytosis at rest (upper panel) and with KCl depolarization (lower panel). Both are from a control experiment. (B) Mean exocytosis rates at resting and depolarized states in control cells (left) and syt IV cells (right). Higher external KCl (40 mM) was used for “resting” syt IV cells due to the much lower frequency of spontaneous events at 4 mM KCl. Traces were recorded ∼5–10 s after applying high KCl (130 mM) to depolarize a cell (see Methods).