Table 1.

Membrane protein expression and acinar cell number and volume in the salivary gland of female SJL mice

	WT	TG	P-value	Fold
AQP-5	4.8 (4.9)	16 (9.6)	0.0233*	3.33
NKCC1	4.8 (2.5)	19 (8.4)	0.0018*	4.00
Z01	0.9 (.36)	1.2 (.75)	0.3912	1.33
C3	3.1 (3.6)	1.9 (1.2)	0.3838	0.61
Skeletal Length	17.6 (2.1)	20.0 (3.6)	0.0304*	1.14
NKCC1 Volume	34.4 (18.5)	55.2 (24.3)	0.0371*	1.60
Nuclei Count	8.9 (2.8)	7.9 (2.3)	0.0004*	0.89

The membrane protein expression data shown are the mean of the number of pixels x their intensity (10⁷) +/− (SD). Ten different fields were imaged on at least 3 different non-consecutive slides (N=4). The volume, length and nuclei count data shown are the mean of the number of cubic microns (NKCC1 volume), microns (skeletal length) and the number of nuclei per acinus (nuclei count) +/− (SD). Between 3–5 stacks were imaged on at least 3 different non-consecutive slides (N=3). Significant differences are indicated (*) and were determined by unpaired student's t-test. AQP-5=Aquaporin-5, NKCC1= Na+/K+/2Cl- cotransporter, ZO1= zona occludens 1, C3= claudin 3, WT = wild type, TG = IL-12 transgenic.