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. Author manuscript; available in PMC: 2011 Apr 1.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Feb 13;20(7):2137–2139. doi: 10.1016/j.bmcl.2010.02.043

Table 2.

HIV and HCV antiviral activities and cytotoxicity assay results for compounds 1–11.


Compds	HIV	Cytotoxicity	HCV	CEM
	Inhibition	IC₅₀, µM^a	Inhibition	IC₅₀, µM^a
	IC₅₀, µM^a		IC₅₀, µM^a
1	>50	>50	25.6	12.5
2	0.36 (±0.12)	>50	1.8 (±0.3)	50
3	>50	>50	4.1	>50
4	2.9 (±1.4)	13.0 (±1.4)	30.1	12.5
5	3.0 (±2.8)	>50	1.5 (±0.3)	82
6	2.4 (±1.4)	>50	4.1 (±1.8)	100
7	<16	16	5.7	<12.5
8	>50	>50	>50	>50
9	6.7 (±2.9)	>50	>50	ND
10	37.1 (±6.1)	>50	>50	50
11	0.3	18.0	1.4	0.46

^a

50 µM is the cutoff for assays. Standard deviation is given in parentheses.