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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Cell Metab. 2010 Jan;11(1):58–69. doi: 10.1016/j.cmet.2009.11.009

Figure 7. Resistance to high-fat diet induced obesity in Kir6.2-KO.

Figure 7

(A) Under a high-fat diet regimen, Kir6.2-KO (n=10) gained less weight (left y-axis) than age- and gender-matched WT (n=10), despite comparable food consumption (right y-axis).

(B) Representative WT and Kir6.2-KO after 90 days of high-fat diet regimen.

(C) High-fat diet accelerated the rate of weight gain compared to regular chow diet in both WT and Kir6.2-KO, as determined by linear regression. However, the weight gain in WT was significantly higher compared to regular diet already at 25 days of the high fat regimen (*, p<0.05, n=10 for both groups), in contrast to 90 days for Kir6.2-KO (‡, p<0.05, n=10 in each group). Furthermore, the weight gained by Kir6.2-KO throughout the high-fat diet regimen was considerably lower compared to WT.

Data are mean±SEM.