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. Author manuscript; available in PMC: 2010 Apr 5.
Published in final edited form as: J Immunol. 2007 Oct 15;179(8):5462–5473. doi: 10.4049/jimmunol.179.8.5462

Table III. Affinity of IL-17A and F for hIL-17RC-Fc using Biacore analysisa.

hIL-17RC-Ig ka (on-rate) kd (off-rate) KD
mIL-17A No detectable binding
mIL-17F No detectable binding
hIL-17A 1.05E+06 4.90E-04 0.469 nM
1.24E+06 4.38E-04 0.352 nM
hIL-17F 9.91E+05 4.31E-04 0.435 nM
1.11E+06 3.84E-04 0.346 nM
a

Soluble receptor was captured onto chips and binding experiments were performed as described in Materials and Methods. Results shown represent data obtained from two independent experiments.