Table III. Affinity of IL-17A and F for hIL-17RC-Fc using Biacore analysisa.
| hIL-17RC-Ig | ka (on-rate) | kd (off-rate) | KD |
|---|---|---|---|
| mIL-17A | No detectable binding | ||
| mIL-17F | No detectable binding | ||
| hIL-17A | 1.05E+06 | 4.90E-04 | 0.469 nM |
| 1.24E+06 | 4.38E-04 | 0.352 nM | |
| hIL-17F | 9.91E+05 | 4.31E-04 | 0.435 nM |
| 1.11E+06 | 3.84E-04 | 0.346 nM |
Soluble receptor was captured onto chips and binding experiments were performed as described in Materials and Methods. Results shown represent data obtained from two independent experiments.