Figure 2. HRD genes with significant fold change (negative for down-regulation) of the expression level during maturation in NOR (A), CIH (B) and CCH (C).
Note that much larger numbers of genes changed the expression level during the development in hypoxia and the lack of overlap between the effects of CIH and CCH. Genes: Atp1a1 = ATPase, Na+/K+ transporting, alpha 1 polypeptide, Atp2a2 = ATPase, Ca++ transporting, cardiac muscle, slow twitch 2, Ctnna1 = Catenin (cadherin associated protein), alpha 1, Dsg2 = Desmoglein 2, Gaa = Glucosidase, alpha, acid, Hand2 = Heart and neural crest derivatives expressed transcript 2, Mef2a/b/c = Myocyte enhancer factor 2A/B/C, Pcdh12/7 = Protocadherin 12/7, Pkp4 = Plakophilin 4, Smyd1 = SET and MYND domain containing 1, Tbx5 = T-box 5.
