TABLE 2.
Values for total T cells and T-cell subsets in sickle cell patients in steady state, sickle cell patients in VOC, and NHC
| Variablea | Value (mean ± SD) for: |
Pb | ||
|---|---|---|---|---|
| HbSS patients |
Normal healthy controls (n = 20) | |||
| VOC (n = 27) | Steady state (n = 20) | |||
| CD3 cells | ||||
| % | 43 ± 4.7 | 43 ± 4.6 | 52 ± 6.5 | >0.05* |
| Abs count (109/liter) | 1.6 ± 1.0 | 1.7 ± 1.0 | 1.6 ± 0.6 | >0.05# |
| CD4 cells | ||||
| % | 17 ± 3.4 | 22 ± 2.9 | 30 ± 4.1 | <0.05*§# |
| Abs count (109/liter) | 0.6 ± 0.4 | 0.9 ± 0.5 | 0.9 ± 0.4 | <0.05*§ |
| CD8 cells | ||||
| % | 26 ± 3.7 | 20 ± 4.1 | 22 ± 3.5 | <0.05*§ |
| Abs count (109/liter) | 1.0 ± 0.5 | 0.8 ± 0.5 | 0.7 ± 0.2 | >0.05 |
| CD4/CD8 ratio | 0.7 | 1.1 | 1.4 | <0.05* |
a
CD3 cells represent total T cells; subsets are CD4 and CD8 cells. Cell numbers are given as percentages of total cells counted and as absolute (Abs) counts.
b
Determined by two-tailed Student t tests. Symbols indicate significant differences (P < 0.05) between HbSS patients in VOC and normal healthy controls (*), between HbSS patients in VOC and steady-state HbSS patients (§), and between steady-state HbSS patients and normal healthy controls (#).