TABLE 2.

Agar dilution MICs of ciprofloxacin (CIP) and finafloxacin (FIN) under normal pH (7.2) and acidic (pH 5.8) conditions against characterized A. baumannii isolates

Strain no.	Amino acid substitutions		MIC (μg/ml)
	GyrA	ParC	CIP normal	FIN normal	CIP acidic	FIN acidic
1			0.06	0.12	2	0.06
2			0.06	0.5	2	0.12
3			0.12	0.12	2	0.06
4			0.12	0.25	1	0.03
5-7			0.12	0.25	2	0.06
8-10			0.25	0.25	2	0.12
11			0.25	0.25	4	0.06
12			0.5	1	2	0.12
13			0.5	1	4	0.12
14			0.5	1	4	0.25
15-17			1	1	4	0.12
18			1	1	8	0.12
19	Ser83-Leu		1	0.5	4	0.12
20	Ser83-Leu		2	1	4	0.06
21	Ser83-Leu		4	1	32	0.25
22	Ser83-Leu		4	8	32	1
23	Glu87-Gly		4	8	32	1
24-26	Ser83-Leu		4	16	32	2
27, 28	Ser83-Leu		4	16	32	1
29	Ser83-Leu		4	32	32	4
30	Ser83-Leu		8	8	32	0.5
31	Ser83-Leu		8	16	32	1
32	Ser83-Leu		16	16	32	1
33	Ser83-Leu		8	16	128	1
34, 35	Ser83-Leu		8	16	128	2
36, 37	Ser83-Leu		16	16	128	2
38	Ser83-Leu		32	16	128	2
39-42	Ser83-Leu		16	16	>128	2
43	Ser83-Leu		32	16	>128	2
44	Ser83-Leu	Glu84-Lys	32	16	>128	4
45, 46	Ser83-Leu	Ser80-Leu	64	16	>128	2
47	Ser83-Leu	Ser80-Phe	64	32	>128	4
48, 49	Ser83-Leu	Ser80-Leu	128	16	>128	2
50	Ser83-Leu	Ser80-Leu	128	16	>128	4
51-53	Ser83-Leu	Ser80-Leu	128	32	>128	2
54-56	Ser83-Leu	Ser80-Leu	128	32	>128	4
57	Ser83-Leu	Ser80-Phe	128	32	>128	4
58	Ser83-Leu	Ser80-Leu	128	64	>128	4
59	Ser83-Leu	Glu84-Lys	128	64	>128	8
60-62	Ser83-Leu	Ser80-Leu	128	64	>128	8
63	Ser83-Leu	Glu84-Lys	>128	64	>128	2
64	Ser83-Leu	Ser80-Leu	>128	64	>128	4
65	Ser83-Leu	Ser80-Leu	>128	64	>128	8
66	Ser83-Leu		32	16	128	2
67,a 68a	Ser83-Leu	Ser80-Leu	>128	64	>128	4

^aadeB overexpressing; isolates 67 and 68 are clinical isolates that are otherwise identical to isolate 66 (based on pulsed-field gel electrophoresis pattern).