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Spleen histopathology of infected guinea pigs receiving the different treatments. Magnification, ×10. (A) Low dose of inhaled PA-824 particles; (B) high dose of inhaled PA-824 particles; (C) oral suspension of PA-824; (D) untreated controls. Note the absence of granulomas in panels B and C, contrasting with the large surface of white pulp affected with large granulomas in panel D.
