TABLE 2.

Histopathological findings in infected guinea pig spleen tissues after the different treatments^a

Treatment	% White pulp with granulomas	Avg size of granulomas	Incidence of caseous necrosis in granulomas	Severity of caseous necrosis in granulomas	% Granulomas with necrosis
Placebo	60-65	Medium	Moderate	Minimal	5-30
Low dose	40-50	Medium	None	NAb	NA
High dose	0-5	Tiny	None	NA	NA
Oral	0-60	Small	Rare	Minimal	NA
Untreated control	30-80	Medium	Occasional	Minimal	20

^aEach cross-section of spleen contained approximately 25 to 35 profiles of lymphoid white pulp, depending on the overall size of the spleen. The percent affected is the estimated percentage of white pulp profiles that contained granulomas.

^bNA, not applicable.