FIG. 3.
Interactions of NNRTIs with the 106th and 179th residues of RTs. Interaction sites of NNRTIs and RTs in the models are shown. (A) Wild-type RT (RTWT) with EFV. (B) RTV106I/V179D with EFV. (C) RTWT with NVP. (D) RTV106I/V179D with NVP. (E) RTWT with ETV. (F) RTV106I/V179D with ETV. In the RTWT and RTV106I/V179D models, carbon atoms appear gray and cyan, respectively. NNRTIs and the 106th and 179th residues are highlighted by the stick configuration. Blue sticks, nitrogen; red sticks, oxygen; light blue, fluorine; light green, chlorine; pink sticks, bromine atoms.