TABLE 1.

Mean pharmacokinetic parameters for the PCp after simulation with twice-daily 0.5-h infusion of 200, 600, or 800 mg linezolid, and the corresponding human reference data

Parameter	Experimental data (mean value) for a dose (mg)/12 h of:						Human dataa (n = 10) for a dose of 600 mg/12 h
	200 (n = 4)		600 (n = 10)		800 (n = 2)
	0-12b	12-24	0-12	12-24	0-12	12-24
Cmax (μg/ml)	4.38	4.79	13.4	14.6	19.2	19.5	14.1 ± 2.8
Tmax (h)	0.5	0.5	0.5	0.5	0.5	0.5
Cres (μg/ml)	0.39	0.31	1.17	1.26	1.15	1.42
t1/2β (h)	6.72	6.27	6.54	6.18	5.01	5.2	5.1 ± 2.6
MRT (h)	8.65	7.95	8.54	8.10	6.55	6.81
AUC (h × μg/ml)	10.1	10.1	32.4	35.4	38.2	47.7	88.1 ± 34.0c
CLtot (liters/h)	14.9	15.1	13.9	12.9	17.2	13.7
V (liter)s	140.7	136.7	129.7	114.9	124.5	102.2
Vss (liters)	119.7	116.9	112.1	100.2	103.9	89.3
Correlation coefficient	0.987	0.983	0.986	0.989	0.995	0.994

^aReference 13.

^bDosing interval (h).

^cAUC_0-24.