TABLE 2.

MIC-related pharmacokinetic parameters and antibacterial effect indices for simulation of 0.5-h infusion of 200, 600, or 800 mg linezolid per 12 h over 48 h against S. aureus and E. faecalis strains

Parameter	Value
	S. aureus RN4220 (MIC = 2 μg/ml)	S. aureus RN4220MutS2 (MIC = 2 μg/ml)	E. faecalis ATCC 29212 (MIC = 2 μg/ml)		E. faecalis Ef1497 (MIC = 2 μg/ml)		E. faecalis Ef1497MutM3 (MIC = 16 μg/ml)
	600 (4.47 × 109)a	600 (3.60 × 109)	200 (3.57 × 108)	600 (7.47 × 108)	600 (8.10 × 108)	800 (7.60 × 108)	200 (3.50 × 108)	600 (7.27 × 108)
Δlog CFU/ml
t0.5	−0.04	−0.21	−0.08	0.04	−0.01	0.08	−0.009	−0.01
t1	−0.07	0.02	0.14	−0.12	−0.05	−0.02	0.02	−0.01
t2	−0.26	0.02	0.09	−0.08	0.08	−0.13	0.06	−0.05
t12	−0.15	0.21	0.14	0.15	−0.12	−0.16	0.29	0.19
t12.5	−0.26	−0.06	0.26	0.10	−0.14	−0.03	0.23	0.22
t13	−0.22	−0.81	0.28	0.16	0.09	−0.16	0.23	0.25
t14	−0.24	−0.58	0.55	0.18	0.13	−0.05	0.41	0.28
t24	−0.17	0.52	0.83	0.32	0.35	−0.04	0.52	0.44
t48	0.32	0.74	1.23	0.53	0.39	−1.16	0.79	0.45
Cmax /MIC
0.5 h	7.77	6.64	2.01	7.17	5.83	9.51	0.30	0.88
12.5 h	7.95	6.64	2.10	7.70	6.99	9.76	0.34	0.90
AUC0-24/MIC (h)	32.9	32.9	10.2	37.1	35.4	42.9	1.24	3.90
T > MIC (% dosing interval)	50.0	66.6	8.08	69.1	69.0	80.9	0.0	0.0
AUBC0-24(h × log CFU/ml)	229.4	228.8	214.0	217.8	215.6	210.5	212.2	217.1
ABBC0-24(h × log CFU/ml)	−1.21	−2.27	5.11	1.32	−1.49	3.60	2.32	−2.66

^aDose (mg/12 h) (inoculum [CFU/ml]).