TABLE 5.
In vivo efficacies of CB-182,561 and vancomycin against S. pneumoniae lung infections in CD-1 female mice
| Compound and dose (mg kg−1) | Mean CFU/ml (SD) | Fraction of control surviving |
|---|---|---|
| Nonea | 2.69 × 108 (6.7 × 107) | 1.0 |
| CB-182,561 | ||
| 12.5 | 1.33 × 108 (7.1 × 107) | 0.49 |
| 25 | 9.36 × 107 (5.1 × 107) | 0.35 |
| 50 | 9.13 × 107 (7.0 × 107) | 0.34 |
| Vancomycin | ||
| 6.25 | 1.81 × 107 (6.9 × 106) | 0.07 |
| 12.5 | 2.85 × 105 (3.1 × 105) | 1.06 × 10−3 |
| 25 | 9.0 × 100 (0.0 × 100) | 3.35 × 10−8 |
a
As a control, 10 ml/kg of 0.01 M saline phosphate buffer, pH 7.4, was used.