TABLE 1.

Values obtained for pharmacokinetic parameters after oral, intramuscular, and intravenous administration of tobramycin to fasted and fed mice (3 animals per point)^a

Property	Mean ± SE for indicated route and condition
	Oral		i.m.	i.v.
	Fed	15-h fasted
Dose (mg/kg)	50	50	10	10
Cmax (μg/ml)	0.33 ± 0.09	7.8 ± 0.95	16.46 ± 0.89	35.26 ± 0.79
Tmax (min)	15	15	15	5
t1/2 (min)	41.61	21.97	17.70	20.33
AUClast (μg·min/ml)	16.43 ± 1.26	423.68 ± 24.23	658.69 ± 37.00	682.93 ± 29.10
AUCinf (μg·min/ml)	18.94	437.80	667.02	687.47
F (%)	0.48	12.40	96.45	100

^aC_max, maximum concentration of drug in serum; T_max, time to maximum concentration of drug in serum; F, bioavailability; t_1/2, half-life; AUC_last, area under the curve from time zero to last determined concentration-time point; AUC_inf, area under the curve from time zero to infinity; i.m., intramuscular; i.v., intravenous.