TABLE 1.
MICs of β-lactams for A. allosaccharophila AL-1 and E. coli DH10B harboring recombinant plasmids pPER-1, pPER-2, and pPER-6 and the E. coli DH10B reference strain
| β-Lactam(s) | MIC (μg/ml) |
||||
|---|---|---|---|---|---|
| A. allosaccharophila AL-1(PER-6) |
E. coli DH10B harboring: |
E. coli DH10B | |||
| pPER-6a | pPER-1 | pPER-2 | |||
| Amoxicillin | >256 | >256 | >256 | >256 | 4 |
| Amoxicillin-CLAb | 12 | 4 | 4 | 6 | 4 |
| Ticarcillin | >256 | >256 | >256 | >256 | 4 |
| Ticarcillin-CLA | 256 | 12 | 16 | 16 | 4 |
| Piperacillin | 4 | 256 | 32 | 256 | 1 |
| Cephalothin | 16 | >256 | >256 | >256 | 2 |
| Cefoxitin | 0.5 | 2 | 2 | 2 | 1 |
| Ceftazidime | 128 | >256 | >256 | >256 | 0.5 |
| Cefotaxime | 2 | 64 | 48 | 64 | 0.12 |
| Cefepime | 0.5 | 32 | 16 | 32 | 0.06 |
| Cefpirome | 0.5 | 8 | 16 | 16 | 0.06 |
| Moxalactam | <0.06 | 2 | 1 | 0.5 | 0.12 |
| Aztreonam | 1 | >256 | >256 | >256 | 0.25 |
| Imipenem | 1 | 0.25 | 0.25 | 0.25 | 0.25 |
| Imipenem-CLA | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 |
| Meropenem | 0.06 | 0.0 | 0.03 | 0.03 | 0.06 |
| Ertapenem | 0.5 | <0.03 | <0.03 | <0.03 | <0.03 |
a
E. coli DH10B(pPER-6) expressed β-lactamase PER-6 from A. allosaccharophila AL-1.
b
CLA, clavulanic acid at a fixed concentration of 4 μg/ml.