TABLE 1.
β-Lactam(s) | MIC (μg/ml) |
||||
---|---|---|---|---|---|
A. allosaccharophila AL-1(PER-6) |
E. coli DH10B harboring: |
E. coli DH10B | |||
pPER-6a | pPER-1 | pPER-2 | |||
Amoxicillin | >256 | >256 | >256 | >256 | 4 |
Amoxicillin-CLAb | 12 | 4 | 4 | 6 | 4 |
Ticarcillin | >256 | >256 | >256 | >256 | 4 |
Ticarcillin-CLA | 256 | 12 | 16 | 16 | 4 |
Piperacillin | 4 | 256 | 32 | 256 | 1 |
Cephalothin | 16 | >256 | >256 | >256 | 2 |
Cefoxitin | 0.5 | 2 | 2 | 2 | 1 |
Ceftazidime | 128 | >256 | >256 | >256 | 0.5 |
Cefotaxime | 2 | 64 | 48 | 64 | 0.12 |
Cefepime | 0.5 | 32 | 16 | 32 | 0.06 |
Cefpirome | 0.5 | 8 | 16 | 16 | 0.06 |
Moxalactam | <0.06 | 2 | 1 | 0.5 | 0.12 |
Aztreonam | 1 | >256 | >256 | >256 | 0.25 |
Imipenem | 1 | 0.25 | 0.25 | 0.25 | 0.25 |
Imipenem-CLA | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 |
Meropenem | 0.06 | 0.0 | 0.03 | 0.03 | 0.06 |
Ertapenem | 0.5 | <0.03 | <0.03 | <0.03 | <0.03 |
E. coli DH10B(pPER-6) expressed β-lactamase PER-6 from A. allosaccharophila AL-1.
CLA, clavulanic acid at a fixed concentration of 4 μg/ml.