FIG. 1.
Genetic constructs for making antibody fusions using the MLV-based retroviral vector. (A) Retroviral construct used to encode the antibody heavy chain fused to an antimicrobial. (B) Retroviral construct used to encode the antibody light chain. LTR, long terminal repeat; EPR, extended packaging region; sCMV, simian cytomegalovirus promoter; SP, signal peptide; VH, heavy-chain variable region; VL, light-chain variable region; CH, heavy-chain constant region; CL, light-chain constant region; RESE, RNA export and stabilization element; (G4S)3, glycine-serine linker; Bioc, biocide.