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. 2010 Feb 1;78(4):1610–1617. doi: 10.1128/IAI.00002-10

FIG. 3.

FIG. 3.

CD1d-dependent activation of NKT cells enhances in vivo protection against lethal toxin. Naïve and immunized mice were challenged i.v. with PA plus LF at the times indicated by arrows. Survival was then monitored daily for the times indicated. (a) Naïve mice, treated with 0, 50, 200, or 300 μg of each toxin subunit. (b) Survival in C57BL/6 and CD1d−/− mice, previously immunized with PA and challenged with 200 μg of each toxin subunit. (c) Survival in C57BL/6 previously immunized with PA alone or PA plus α-GC and challenged with the 200-μg dose on day 0 and then the 100-μg dose on day 1. Numbers of mice per group are indicated.