FIG. 4.
Histopathology of tissues of taut−/− mice that succumbed to P. chabaudi malaria. (A, B, and C) Slices of the brain including the cortex cerebri. Histological changes of the brain (A and C) include the presence of several parasitized erythrocytes in the cerebral blood vessels, infiltration of malarial-pigment-containing hypertrophic monocytes (A, arrow), endothelial cell activation with enlarged nuclei (C, black arrows), adherence of mononuclear cells to endothelial cells of small cerebral vessels, and focal vessel disruption (C, white arrow) with perivascular hemorrhage (C, double-headed arrow). Arrows in panel B show isolectin IB4 antibody staining of stimulated murine macrophages in a blood vessel. (D) Slices of heart muscle show interstitial edema, differences in the sizes of cardiomyocytes, and abnormal, thinner myofibers with a wavy appearance. (E) Pulmonary edema of the lung. (F) Hemorrhagic infarct of the lung. (G) Isolectin staining showing interstitial stimulated murine pigment-containing macrophages/monocytes in the lung. (H) Arrows indicate chromoprotein cylinders in the kidney. (I) Double-headed arrow shows tubular necrosis in the kidney. (K) Small and large arrows indicate small and large necrotic areas in the liver. Some tissues were stained with hematoxylin and eosin (A, C, D, E, and F) or were subjected to immune staining with the FITC-labeled isolectin IB4 antibody (B and G). Original magnifications, ×400 (A, B, C, and D), ×100 (E, G, H, and K), and ×200 (F and I).