TABLE 2.
Serum parameters of P. chabaudi-infected taut+/+ and taut−/− mice on days 0 and 8 p.i.a
| Parameter | Day 0 p.i. |
Day 8 p.i. |
P (day 8 p.i. vs day 0 p.i.) |
|||||
|---|---|---|---|---|---|---|---|---|
| Mean value ± SEM (no. of mice) |
P (taut−/− vs taut+/+ mice) | Mean value ± SEM (no. of mice) |
P (taut−/− vs. taut+/+ mice) | |||||
| taut+/+ | taut−/− | taut+/+ | taut−/− | taut+/+ mice | taut−/− mice | |||
| IL-1β (ng/liter) | 1.27 ± 0.1 (3) | 2.1 ± 0.2 (3) | 0.15 | 4.7 ± 1.1 (3) | 14.5 ± 1.9 (3) | <0.01 | 0.05 | 0.02 |
| IL-6 (ng/liter) | 1.2 ± 0.1 (3) | 2.1 ± 0.5 (3) | 0.37 | 39.1 ± 12.3 (5) | 69.4 ± 22.6 (5) | 0.25 | <0.01 | <0.01 |
| TNF-α (ng/liter) | 23.8 ± 0.6 (4) | 27.3 ± 2.1 (4) | 0.22 | 29.4 ± 6.2 (5) | 97.2 ± 23.6 (5) | <0.01 | 0.46 | 0.02 |
| Total NO (μmol/liter) | 25 ± 2 (3) | 74 ± 41 (3) | 0.35 | 118 ± 9 (4) | 198 ± 35 (3) | 0.08 | <0.01 | 0.02 |
a
Blood was taken from mice, and serum was prepared and analyzed, as described in Materials and Methods. Significance was evaluated with Student's t test; P values of <0.01 were considered significant. γ-Glutamyltransferase activity was lower than 3 U/liter in all samples.