FIG. 4.

(A) Linkage map showing C. burnetii bcp with proximal genes, derived from genomic sequence data for Nine Mile strain RSA 493 (22). Note the overlap of sdr with the 3′ end of bcp and the inverted but closely linked CBU_0964 and CBU_0961 ORFs. (B) A possible mechanism whereby BCP serves as an atypical 2-Cys Prx enzyme for hydroperoxides, based on the model of Kong et al. (16). A predicted role of Trx as an electron donor that reduces BCP through a cysteine thiol-disulfide exchange (plus TrxR for reduction of the Trx disulfide bond) is shown.