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Failure to activate IRF-7 enhances the replication and spread of NDV. SVHUC1, 2fTGH, U3A, and U6A human fibrosarcoma cells were either mock infected or infected with the rLaSota V.F., rBC, or rBC-Edit strain of NDV at an MOI of 10. Virus replication and spread indicated by EGFP expression in SVHUC1 (IRF-7+) (A) and IRF-7-hypermethylated wild-type and mutant human fibrosarcoma cells (B to D). (B) 2fTGH cells; (C) U3A cells; (D) U6A cells.
