FIG. 5.

Interferon-sensitive NDV strains regress xenotransplanted tumors in nude mice as efficiently as an interferon-antagonistic NDV strain. BALB/c nude mice were subcutaneously implanted with HT1080 human fibrosarcoma tumor cells. When tumors reached a size of >5 mm in any one plane, recombinant NDV strains were administered intratumorally as a single injection (2 × 10⁷ PFU/ml in 50 μl). (A) Mock-infected mice with tumors on day 31; (B) tumor-bearing mice treated with rBC-EGFP virus; (C) mice treated with rBC-Edit virus; (D) mice treated with rLaSota V.F. virus on day 31 posttreatment. (E) Calculated tumor volumes for each virus strain were plotted against days postinoculation. Results are mean values plus standard errors of the means from three BALB/c mice.