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Working model of events that lead to fusion. Cartoon representation of gB trimer and gD dimer with domains color coded as in the crystal structures previously published (19) and Fig. 1. Receptor and receptor bound to gD (HVEM is depicted) are shown in purple. Heterocomplex gH/gL is shown in blue, nonfluorescent YFPN and YFPC halves in white, and reconstituted YFP in yellow. CM, cell membrane. Arrowheads point to extended gB fusion loops (step 2).
