TABLE 1.
Parameters of the innate-response model
| Parameter | Symbol | Unit | Value | Reference |
|---|---|---|---|---|
| Epithelial cell population | T0 | Cells | 3.5 × 1011 | 46 |
| Initial virus load | V0 | RNA copies (ml NS)−1 | Fitted | |
| Infectivity rate | β | (RNA copies)−1 ml NS day−1 | Fitted | |
| IFN-reduced infectivity | m | 1 | ||
| Virus production | p | RNA copies (ml NS)−1 day−1 cell−1 | Fitted | |
| Free-virus clearance | c | Rate of virus clearance day−1 | 5.2 | 2 |
| IFN efficiency | φ | (IFN fold change)−1 day−1 | Fitted | |
| IFN production | q | IFN fold change day−1 cell−1 | Fitted | |
| IFN-reduced production | n | 1 | ||
| IFN clearance | d | Rate of IFN clearance day−1 | Fitted | |
| Eclipse phase period | 1/ki | Days | 1/2 | 23 |
| Infectious period | 1/δ | Days | 1/2 | 23 |
| Prerefractory state | 1/a | Days | 1/4 | 11 |