TABLE 2.
Tissue necropsy report for MPXV-infected C57BL/6 stat1−/− micea
| Tissue | Diagnosis | Severity | No. examined |
|
|---|---|---|---|---|
| Infected | NI | |||
| Brain | 7 | 2 | ||
| NSML | 3 | 2 | ||
| Ventriculitis, acute | Minimal | 1 | ||
| Leptomeningitis, acute | Mild | 4 | ||
| Kidney | 7 | 2 | ||
| NSML | 7 | 1 | ||
| Proteinosis, tubular | Minimal | 1 | ||
| Liver | 7 | 2 | ||
| NSML | 2 | 2 | ||
| Hematopoiesis, extramedullary | Minimal | 2 | ||
| Mild | 2 | |||
| Inflammation, subacute | Minimal | 2 | ||
| Mild | 1 | |||
| Spleen | 7 | 2 | ||
| NSML | 2 | |||
| Hematopoiesis, extramedullary | Minimal | 1 | ||
| Mild | 1 | |||
| Moderate | 3 | |||
| Severe | 2 | |||
| Apoptosis, lymphoid | Mild | 1 | ||
| Lung with bronchi | 7 | 2 | ||
| NSML | 3 | 1 | ||
| Inflammation, subacute | Mild | 1 | ||
| Pneumonia, bronchointerstitial, acute | Mild | 1 | ||
| Histiocytosis, alveolar | Mild | 1 | ||
| Hyperplasia, lymphoid | Mild | 2 | 1 | |
| Adrenal gland | 7 | 2 | ||
| NSML | 6 | 2 | ||
| Degeneration, cortical | Minimal | 1 | ||
| Thyroid | 7 | 2 | ||
| NSML | 6 | 2 | ||
| Inflammation, subacute | Mild | 1 | ||
| Larynx | 7 | 2 | ||
| NSML | 5 | 1 | ||
| Inflammation, lymphoplasmacytic | Mild | 2 | 1 | |
| Lymph node, mandibular | 7 | 2 | ||
| NSML | 1 | 2 | ||
| Hyperplasia, lymphoid | Moderate | 4 | ||
| Inflammation, acute | Mild | 2 | ||
| Apoptosis, lymphoid | Mild | 2 | ||
| Moderate | 1 | |||
| Trachea | 7 | 2 | ||
| NSML | 5 | 1 | ||
| Inflammation, acute | Minimal | 1 | ||
| Inflammation, lymphoplasmacytic | Mild | 1 | ||
| Moderate | 1 | |||
| Heart | 7 | 2 | ||
| NSML | 5 | 2 | ||
| Hemosiderosis, valvular | Minimal | 1 | ||
| Mild | 1 | |||
| Optic nerve | 5 | 2 | ||
| NSML | 4 | 2 | ||
| Leptomeningitis, acute | Mild | 1 | ||
| Bone marrow, sternum | 7 | 2 | ||
| NSML | 4 | 2 | ||
| Hyperplasia, myeloid | Mild | 1 | ||
| Moderate | 2 | |||
| Bone marrow, femur | 7 | 2 | ||
| NSML | 1 | 2 | ||
| Hyperplasia, myeloid | Mild | 1 | ||
| Moderate | 5 | |||
| Nasal cavity | 7 | 2 | ||
| NSML | 2 | 2 | ||
| Rhinitis, fibrinopurulent | Mild | 1 | ||
| Moderate | 3 | |||
| Severe | 1 | |||
| Thymus | 7 | 2 | ||
| NSML | 1 | 2 | ||
| Atrophy, cortex | Mild | 1 | ||
| Severe | 1 | |||
| Atrophy, lymphoid | Mild | 1 | ||
| Severe | 3 | |||
| Ovary | 7 | 2 | ||
| NSML | 6 | 2 | ||
| Inflammation, acute | Moderate | 1 | ||
| Oviduct | 7 | 2 | ||
| NSML | 6 | 2 | ||
| Inflammation, acute | Moderate | 1 | ||
a
No significant microscopic lesions (NSML) reported in adrenal gland, aorta, cecum, colon, duodenum, esophagus, eye, gallbladder, Harderian gland, heart, ileum, jejunum, kidney, lymph node (mesenteric), mammary gland, optic nerve, pancreas, parathyroid, prostate, rectum, salivary gland, skeletal muscle, tongue, urinary bladder, penis, seminal vesicle, skin, skeletal muscle, spinal cord, stomach, testes, thyroid, tongue, trachea, urinary bladder, uterus with cervix, and vagina.