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Distribution of serotypes of macrolide resistant invasive S. pneumoniae strains isolated from adult patients (1999 to 2007). Lettered brackets: a, significant decrease in MR IPD due to serotype 6B in early-PCV7 compared to late-PCV7 periods; b, significant decrease in MR IPD due to serotype 6B in pre-PCV7 compared to late-PCV7 periods; c, significant increase in MR IPD due to serotype 24F in pre-PCV7 compared to late-PCV7 periods.
