TABLE 5.
Comparison of conventional RIF DST to rpoB gene pyrosequencing for 143 clinical specimensa
| No. of specimens | Conventional RIF DST result | Result of pyrosequencing of rpoB |
|---|---|---|
| 139 | S | Wild type (S) |
| 2 | R | Mutation (R) |
| 1 | S | Mutation (R)b |
| 1 | R | Wild type (S)c |
a
The data are for the same set of specimens used to obtain the data presented in Table 4, but the five specimens with inconclusive pyrosequencing results were excluded from this analysis. S, susceptible; R, resistant.
b
Asp516Tyr mutation with known poor predictive value.
c
Mutation determined to be within the rpoB gene outside of the 81-bp region, Val176Phe.