TABLE 5.

Trends in in vitro resistance to fluconazole among Candida spp. as determined by CLSI disk diffusion testing over a 10.5-year period^a,b

Species	1997-2000		2001-2004		2005-2007
	No. of isolates tested	% R	No. of isolates tested	% R	No. of isolates tested	% R
C. albicans	39,152	0.9	71,027	1.4	57,598	1.4
C. glabrata	5,634	19.2	12,963	15.9	10,342	15.4
C. tropicalis	2,996	3.6	8,496	4.5	7,050	3.6
C. parapsilosis	2,633	2.5	7,783	3.5	5,005	3.6
C. krusei	1,207	65.8	2,840	77.5	2,239	79.3
C. guilliermondii	367	12.5	902	9.9	508	14.2
C. lusitaniae	276	2.9	674	4.3	559	6.6
C. kefyr	182	3.3	527	3.6	517	1.7
C. inconspicua	9	55.6	276	52.2	290	54.1
C. famata	123	17.1	375	12.5	247	6.9
C. rugosa	35	34.3	238	50.7	134	10.4
C. dubliniensis	1	0.0	113	2.7	197	2.0
C. norvegensis	11	54.5	135	36.3	113	46.0
C. lipolytica	7	0.0	80	37.5	50	14.0
C. sake			20	10.0	67	11.9
C. pelliculosa	1	0.0	47	0.0	40	15.0
C. apicola					57	1.8
C. zeylanoides	4	0.0	50	28.0	20	15.0
C. valida			9	66.7	12	58.3
C. intermedia			10	0.0	14	7.1
C. pulcherrima			6	0.0	8	0.0
C. haemulonii			6	0.0	3	33.3
C. stellatoidea					7	0.0
C. utilis					6	0.0
C. humicola			2	50.0	4	50.0
C. lambica					5	80.0
C. ciferrii					2	50.0
C. colliculosa					2	0.0
C. holmii					1	0.0
C. marina					1	0.0
C. sphaerica					1	0.0
Candida spp.c	2,591	10.5	6,186	8.2	3,558	10.1

^aIncludes all specimen types and all hospital locations in 141 institutions.

^b% R, percent resistant (zone diameter, ≤14 mm).

^cCandida species not otherwise identified.